United States: A new analysis concludes that GLP-1 receptor agonists enhance pre-meal satiety through neurons within the dorsomedial hypothalamus.
More about the finding
In this regard, the intervention of GLP-1 receptor agonists in the augmentation of the level of satiety can be of great benefit to treat this problem of overeating and play an imperative role in the prevention of obesity where this new knowledge about the neurological function aids the researchers in the study.
Consequently, the feeling of satiety or the ability to recommend that one has had enough food must be signaled and include some agents like glucagon-like peptide 1(GLP-1).
Preingestive satiation, the feeling of fullness before eating, helps regulate internal status and food intake.
GLP-1 receptor agonists (GLP-1RAs) have proven effective in treating obesity by influencing food perception, reducing hypothalamic activity in response to food cues, and altering food appeal, according to neurosciencenews.com.
What more have the findings suggested?
It suggests that GLP-1RAs regulate food intake by inducing preingestive satiation.
However, the effects depend on various factors, and the precise targets of GLP-1RAs need further study.
Kyu Sik Kim and colleagues examined clinical trial outcomes for obese individuals.
Surveys measuring baseline, pre-ingestive, and ingestive satiation were conducted with or without GLP-1RA on a controlled diet, excluding the treat meal.
The main parameters of this study were evaluated as follows: GLP-1RA treatment resulted in a statistically significant increased satiation index (overall feeling of fullness) at all phases of the study, while the control group profile demonstrated a significant decline from baseline at the pre-ingestive phase level.
During the pre-ingestive phase, GLP-1RA significantly changed the satiation index compared with the baseline and improved the steps of prospective food ingestion, food reward, and the motivation satiation index, as neurosciencenews.com reported.
In their research, Kim and others studied brain tissues from both humans and mice to determine circuits that are involved in the interaction between the dorsomedial hypothalamus and these agonists that enables the reduction of food desire.
Activation of these neurons using optogenetics leads to satiation, while calcium imaging suggests that these neurons are involved in the encoding of preingestive satiation.